Your doctor will probably tell you not to take tadalafil if you are taking nitrates. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Tadalafil is a type of drug used to increase blood flow to the sex organ of males. Tadalafil works for these conditions by promoting muscle relaxation, which improves blood flow in PAH and urinary flow in BPH. Also, patients that are currently taking medicines with substances such as nitrates and guanylate cyclase stimulators should avoid Tadalafil to prevent unsafe drop or increase in blood pressure. If you experience chest pain, dizziness, or nausea during sexual activity, call your doctor immediately or get emergency medical treatment, and avoid sexual activity until your doctor tells you otherwise.Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Tadalafil is also sometimes taken once a day every day without regard to timing of sexual activity. Cialis (tadalafil) is a popular medication used to treat erectile dysfunction. It’s available in tablets ranging from mg to 20mg. It can cost more than $ for a month’s supply, depending on the dosage you need and the pharmacy you visit. You can save more than 90% on the average retail price at certain pharmacies by using a GoodRx coupon. How much does tadalafil cost without insurance? The cost of tadalafil without insurance starts at $* for 20mg and 30 tablets using an RxSaver coupon.. If you’re prescribed tadalafil to treat erectile dysfunction or to alleviate symptoms of an enlarged prostate, you’ll be glad to know that the medication is very affordable when you .