This medication is taken with or without food an hour before sex. These medicines are called PDE5 inhibitors. The body takes longer to absorb it after a high-fat meal or alcohol. An OTC drug will help patients get treatment more quickly. Men were also turning to unlicensed and potentially harmful remedies, such as Kamagra an oral jelly that claims falsely to contain the same ingredients as Viagra. Clinical trials for MED found minimal side effects. It lasts 4 to 5 hours, or longer if you have mild to moderate ED.”The 5-mg difference between sildenafil and the lowest dose of Viagra could easily be made up by taking an extra half pill, if needed,” says Consumer Reports’ chief medical adviser, . Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric . 7 Over The Counter Medications for ED. Depending on the cause of erectile dysfunction, the most effective treatment can vary. Typically, the best way to treat erectile dysfunction .