Premature ejaculation: state of the art. Dapoxetine: an evidence-based review of its effectiveness in treatment of premature ejaculation. Disorders of orgasm and ejaculation in men. Pelvic floor exercises Kegel exercises can help strengthen these muscles. With whom, and under what circumstances? Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Be careful not to flex the muscles in your abdomen, thighs or buttocks.Dapoxetine is the only SSRI specifically designed to treat PE. Mechanism of action: Dapoxetine hydrochloride is a potent inhibitor of serotonin reuptake transporters. . Premature ejaculation (PE) is a prevalent male sexual dysfunction. Current standard treatment regimens include behavioural therapies, topical anaesthetics, . Clinical Question Are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) safe and effective for the treatment of .