Cyclic GMP relaxes and widens the blood vessels in the penis, allowing more blood to enter. Do not take Viagra more than once in any 24 hours. Sildenafil works by stopping this enzyme from breaking down the cyclic GMP. Another brand of sildenafil tablets called Revatio is often used in this condition. This is a drug known as a PDE5 inhibitor. Viagra Connect can be taken with or without food, however the medicine may take longer to start working after a heavy meal. In the search for the best ED medication out there, many men will find this a preferable option.Viagra Connect is a medication used to treat Erectile Dysfunction in men. It contains the ingredient sildenafil at a dose of From 11th January , Viagra Connect has become available to purchase as an over-the-counter medicine from pharmacies in Ireland, having previously been subject to a prescription by a doctor. Viagra Connect, Viagra and Sildenafil are erectile dysfunction treatments that work within your body to help you achieve and maintain an erection that is hard enough for sexual intercourse. The treatment allows the blood vessels within the body to expand and relax, causing blood to flow to the penis, resulting in an erection. Viagra Connect is a medicine used to treat erectile dysfunction (ED) in men. Once you have taken Viagra Connect, it stays active in your body for up to four hours. 1 After that, the medicine gets broken down by the liver and is flushed out of the body. It’s important to note that although Viagra Connect can stay active for up to four hours.